Showing posts with label mefloquine. Show all posts
Showing posts with label mefloquine. Show all posts

Thursday, December 13, 2018

Navy SEAL sues drug company for all others given Lariam

Navy SEAL Sues Roche over Malaria Drug, Claiming it Left Him Permanently Disabled


Military.com
By Patricia Kime
12 Dec 2018

According to the Sheetses' lawyer, Kevin Boyle, the case is significant because it could "vindicate the fact that many veterans are suffering from a legitimate condition" and "ensure that those who are responsible for these serious injuries are held accountable."
Mosquito close-up. Getty Images 
A former Navy SEAL has filed a lawsuit against the company that makes the anti-malarial drug Lariam, or mefloquine, alleging that the medication left him permanently disabled after taking it while serving in Afghanistan.

Andrew Sheets and his wife, Kristie, of Cazadero, California, allege that pharmaceutical giant Hoffman-LaRoche, known as Roche, was aware that the drug caused serious neurological and psychiatric side effects and failed to warn patients of the dangers.

Sheets, who served in the U.S. Navy from 2000 to 2006, said he immediately experienced "violent and tragic nightmares" the first time he took Lariam, during a deployment in 2003. He later developed psoriasis, extreme paranoia, hallucinations, anxiety and suicidal thoughts.

"In February 2017, Mr. Sheets was finally described as permanently disabled by his treating physician because of his debilitating, Lariam-related mental disorders," court documents state.

For more than two decades, Lariam, also known by the generic name mefloquine, was distributed to troops to prevent malaria in endemic countries. At the peak of military use in 2003, nearly 50,000 prescriptions for mefloquine were written by military doctors.
read more here

Saturday, October 20, 2018

Some meds became the ties that bind veterans to suffering

What have we done to our veterans?

Combat PTSD Wounded Times
Kathie Costos
October 20, 2018


In 2004, the US Department of Veterans Affairs issued a warning on Lariam following a warning from the FDA the year before. VA Dr. Jonathan Perlin wrote it "may rarely be associated with certain long-term chronic health problems that persist for weeks, months, and even years after the drug is stopped."

There were suspected links to suicides, including Spec. Adam Kuligowski, Afghanistan veteran from Fort Campbell 101st Airborne Division. His father said that the drug was found in his system.

It was suspected in the case of Staff Sgt. Robert Bales, convicted of killing 16 Afghans. He had PTSD and TBI. He was on his third tour when it happened. His case caused the military to stop using it in 2009.

Dr. Remington Nevin, epidemiologist and Army Major said "Melfoquine is a zombie drug. It's dangerous, and should have been killed off years ago. He added it was "toxic to the brain."

It is possible that this drug had something to do with crimes committed in Canada as well. The thing is, the veteran should have to pay for what he did, but should not be further punished with incarceration without psychological treatment.

This drug was given to many NATO forces. We should all be asking, "What have we done to our veterans?"


*******

Controversial anti-malaria drug an element in Mark Donlevy's actions, says defence lawyer

CBC
Dan Zakreski
October 19, 2018
Donlevy is also scheduled to stand trial later this fall on 11 other sexual assault charges related to when he worked as a massage therapist in the city.
The lawyer for a former Saskatoon massage therapist guilty of sexual assault said Friday that his client was given a controversial anti-malaria drug in 1992, and the effects haunt him still.
Mark Donlevy at Court of Queen's Bench. (CBC)
Alan McIntyre raised the point during sentencing arguments for Mark Donlevy, at the Court of Queen's Bench in Saskatoon.

Donlevy was found guilty in September of sexually assaulting a woman he met through an online dating site. McIntyre argued for a three-year sentence, while prosecutor Cory Bliss said three-and-a-half years is more appropriate.

McIntyre raised the issue of the impact of the anti-malaria drug, while providing Justice Heather MacMillan-Brown with personal details about Donlevy's life.

McIntyre said that Donlevy took the anti-malarial drug while he was in Somalia serving with the Canadian military, and that it has affected him since then.
read more here

Thursday, May 17, 2018

Army Staff Sgt. Robert Bales take case to Supreme Court?

Lawyers claim anti-malaria drug to blame in US soldier's Afghan massacre
ABC News
By ELIZABETH MCLAUGHLIN
May 16, 2018

In July 2013, the U.S. Food and Drug Administration (FDA) even revised its warning label for the drug, saying rare but sometimes permanent side effects include "dizziness, loss of balance, and ringing in the ears," as well as "feeling anxious, mistrustful, depressed, or having hallucinations."

Lawyers for former Army Staff Sgt. Robert Bales are asking the U.S. Supreme Court to consider that the malaria drug mefloquine may have played a role in Bales' murder of 16 Afghan civilians during his deployment.
On March 11, 2012, Bales was on his fourth combat tour stationed in Panjwai District of Kandahar Provence, Afghanistan when he left his post and killed 16 Afghans, including women and children, in two nearby villages.

In August, 2013, Bales was sentenced to life without parole by a military jury.

Hamid Karzai, president of Afghanistan at the time, suggested the U.S. should try and hang Bales.

At the time, the soldier was taking medication to prevent malaria called mefloquine, which his lawyers argue contributed to his behavior that night. They are now petitioning the Supreme Court to review the case, saying government prosecutors did not disclose that Bales was ordered to take the drug before and during his deployment.

Court records show that after Bales' first deployment to Iraq in 2004 he complained of memory impairment and depression. And after later deployments, he complained about insomnia, irritability, anger, decreased ability to concentrate, and memory impairment.
read more here

Thursday, May 3, 2018

Mefloquine raises ugly head again

Mefloquine or Medusa and where is Perseus?

Veterans allege devastating side effects from anti-malaria drug they were ordered to take
WHAS ABC 11 News
Author: Andrea McCarren
May 3, 2018

More than a million Americans are believed to have taken the anti-malaria drug called mefloquine. But veterans, former Peace Corps volunteers, government employees and world travelers say they've suffered acute side effects that are getting progressively worse.

For decades, the Department of Defense ordered tens of thousands of American service members to take a drug intended to prevent malaria, a mosquito-borne disease that can kill. And now, veterans, former Peace Corps volunteers, federal employees and world travelers believe mefloquine caused some acute psychiatric and physical conditions that they say are getting progressively worse.

Mefloquine was sold under the brand name Lariam until its manufacturer stopped producing the drug in 2008. Generic versions are still available in the United States, but only by prescription. Common side effects attributed to the drug include paranoia, anxiety, depression and neurological issues, including vertigo and tinnitus, which is the perception of noise or ringing in the ears.

"We have a hidden epidemic of veterans who are suffering the chronic neuropsychiatric effects of mefloquine poisoning," said Dr. Remington Nevin, widely considered the world's expert in the potential side effects of mefloquine. "And in many cases, they’re being misdiagnosed. Misdiagnosed with conditions such as post-traumatic stress disorder."
read more here


We have been reading about this since 2008. Why are we still reading about it now?
VA issued a warning about Lariam in 2004. By 2012 after Staff Sgt. Robert Bales shot 17 in Afghanistan, later found guilty, the military "scrambled" to limit it. By 2013, the Green Berets and other Special Forces units stopped using it.

BY 2015, reports were coming out from Australia and a veteran said, "At various times it was like living in a heavily armed lunatic asylum" after taking it. In 2017, Canada was also faced with problems. 

So why after all these years are we still talking about it and who is responsible for what it did to the men and women the military gave it to?

Saturday, June 3, 2017

Mefloquine Residual in Veterans Back in News Out of Australia

This report is about Australia veterans but they are just as human as US veterans are and fighting for the truth.
Veterans say report on anti-malaria drug mefloquine downplays side-effects
The Guardian
Melissa Davey
June 2, 2017

Former soldiers say they were not properly informed of potential hazards, including neurological problems, suicidal thoughts and nightmares
“The main issue of concern is the chronic health effects experienced by the 5,000 personnel given mefloquine and tafenoquine since the early 1990s,” McCarthy said. “Drug regulators including the US Food and Drug Administration warn that mefloquine is able to cause neuropsychiatric side effects that may persist or become permanent.
An unpublished government report on an anti-malarial drug given to thousands of Australian soldiers has been criticised by a decorated war veteran for downplaying the drug’s side-effects.

Mefloquine, also known as Lariam, was given to soldiers deployed to Bougainville and Timor-Leste more than 15 years ago as part of clinical trials comparing its efficacy to doxycycline, an antibiotic and the first-line medication for malaria prevention in the Australian defence force.

Since then there have been well-documented questions raised about the consent process for the soldiers involved in the trials, and veterans have said they were not properly informed of mefloquine’s potential side-effects. Veterans have also spoken of symptoms including suicidal thoughts, hallucinations and nightmares which they attribute to being on the drug, sometimes emerging years later. They have accused researchers of downplaying the extent of severe side-effects such as neurological issues.
read more here

Other reports going back to 2008

VA ISSUED WARNING ON LARIAM IN 2004
ARMY CURBS PRESCRIPTIONS OF ANTI-MALARIA DRUG MEFLOQUINE
WHEN THE CURE IS WORSE THAN THE DISEASE MILITARY SCRAMBLE TO LIMIT MALARIA DRUG
In 2013 Green Berets and other Special Forces stopped using it.

Tuesday, January 24, 2017

Canada Veterans Need to Look At US Reports on Mefloquine

In 2008 the VA issued a warning about Mefloquine, and there are other stories on this report going back to 2002.

Senator Dianne Feinstein wanted answers from Donald Rumsfeld in 2003
Veterans, families want answers over Forces' use of Mefloquine
Toronto Sun crime reporter Chris Doucette. (Sun files)
By Chris Doucette, Toronto Sun
Monday, January 23, 2017

The call for accountability over the Canadian Forces’ use of a controversial anti-malaria drug is growing louder and veterans and family members hope Prime Minister Justin Trudeau will hear their cries for help.

A former medic who served in Somalia, the wife of a soldier disgraced in the Somalia Affair, the mother of a soldier who killed himself in Rwanda and a doctor with expertise in the neuropsychiatric effects of Mefloquine toxicity recently submitted written statements to the Standing Committee on Veterans Affairs outlining the drugs’ devastation.

Marj Matchee writes her husband, Clayton, suffered paranoia and hallucinations prior to his 1993 arrest for the deadly beating of a Somali teen.

“You see things when you sleep. You see it in the daytime too,” she recalls him saying.

Many veterans who were forced to take the drug before it was licensed still suffer from side effects that Health Canada and AA Pharma, the Canadian supplier of the drug, quietly added to Mefloquine’s warning label last year.

“We must do more to reach out to these veterans, to acknowledge the harms that Mefloquine has caused them, and commit to funding research to study and ultimately try to reverse these effects,” Matchee writes.

Dr. Remington Nevin, of Johns Hopkins University, says Mefloquine toxicity can cause brain damage that mimics PTSD, so sufferers may receive the wrong treatment and symptoms such as suicidal thoughts persist.
read more here
These may help their case
Lariam Psychiatric and Suicidal Side Effects Research shows the anti-malaria drug mefloquine hydrochloride—formerly sold under the brand name Lariam—might cause psychiatric abnormalities, suicidal ideations and behaviors, and potentially permanent nerve damage. Because of these psychiatric side effects, the drug’s manufacturer, Hoffmann-La Roche, pulled it from the market in 2008. The U.S. Army continued to administer it to soldiers, however, until 2011, when the army ceased prescribing Lariam even for soldiers deployed in malaria-prone regions such as Afghanistan. In July 2013, the U.S. Food and Drug Administration (FDA) notified the public that mefloquine products’ drug labels would be updated with a black box warning—the agency’s most serious kind—concerning the aforementioned side effects.

Monday, March 14, 2016

Australian Defence Force Face Off With Soldiers Over Lariam

Former soldiers, families face military officials in Townsville over anti-malaria drug side effects
ABC Australia
By Jesse Dorsett
Updated yesterday at 7:28pm

PHOTO: Mefloquine, also known as Lariam, is known to cause mental health problems.
(Flickr: David Davies)

The military's top brass has come face to face with former soldiers and their families suffering depression and anxiety after being given controversial anti-malaria drugs on deployment.
Key points: 2,000 ADF personnel given anti-malaria drug in East Timor over five years
Drug side effects include mood swings and suicidal thoughts
ADF says they did not know drugs would produce chronic problems
A forum has been held in Townsville, in north Queensland, to give former soldiers, ex-service organisations and health professional the chance to discuss the effects of anti-malaria medication Mefloquine, as well as the drug Tafenoquine.
Nearly 2,000 Australian Defence Force (ADF) personnel were prescribed Mefloquine, also known as Lariam, primarily in East Timor, between July 2000 and June 2015.

The drug is known to cause agitation, mood swings, panic attacks, confusion, hallucinations, aggression, psychosis and suicidal thoughts in a small number of patients.

Another 492 took Tafenoquine as part of a trial in 2000 and 2001.
read more here and remember US soldiers took it too!

Sunday, November 29, 2015

Australia Soldiers Say Mefloquine Left Them Scarred

Soldiers fear drug program has scarred them with depression, anxiety, nightmares
Sydney Morning Herald
Henry Belot
November 29, 2015

"At various times it was like living in a heavily armed lunatic asylum."
ADF veteran prescribed Lariam
Major Stuart McCarthy is calling for a public inquiry into the ADF's use of antimalarial drug mefloquine. Photo: Brendon Thorne
Australian soldiers and veterans are calling for an immediate inquiry into the use of an antimalarial drug they believe scarred them with permanent psychological damage, anxiety attacks, vertigo, nightmares, suicidal thoughts and hallucinations.

The group, which includes commandos and officers who have served in Iraq and Afghanistan, believe they have been incorrectly diagnosed with post-traumatic stress disorder or depression and were ignored by the military after raising concerns about the drug.

The Inspector-General of the Australian Defence Force has launched an internal inquiry into the use of the drug mefloquine, or Lariam, which has been used on up to 2000 personnel since a controversial drug trial in East Timorin 2001-02.

Major Stuart McCarthy was prescribed mefloquine while serving in Ethiopia and Eritrea in 2001 and has since suffered depression, vertigo, hearing and memory problems and cognitive impairment.

Major Stuart McCarthy was prescribed mefloquine while serving in Ethiopia and Eritrea in 2001 and has since suffered depression, vertigo, hearing and memory problems and cognitive impairment. Photo: Brendon Thorne
But documents obtained by Fairfax Media reveal Chief of Army Lieutenant-General Angus Campbell does not support a campaign against the drug because it would deny deployment opportunities, despite acknowledging the side effects.
"I have been an army officer 27 years and I have no trust in the Australian Defence Force's handling of this matter," he said. read more here

Monday, June 8, 2015

Did Sgt. Robert Bales Receive Fair Trial?

Just a reminder of what else was reported before Bales was convicted,
Antimalarial Drug Linked to Sgt. Robert Bales Massacre
ABC News
By SUSAN DONALDSON JAMES
Digital Reporter
via GOOD MORNING AMERICA
July 22, 2013
Mefloquine was developed by the U.S. military and has been used for more than three decades by the government to prevent and to treat malaria among soldiers and Peace Corps workers.

But the drug can cause varying neurological side effects 5 to 10 percent of the time, according to Dr. David Sullivan, an infectious disease specialist at Johns Hopkins Malaria Research Institute in Baltimore.

The manufacturer also warns against prescribing it to anyone who has suffered a seizure or brain injury, according to the drug label.

Bales told a military court he had "no good reason" to kill.

As you can see in the latest report, that was exactly what he sought treatment for,
Robert Bales makes bid for mercy: ‘There isn’t a why; there is only pain’
The News Tribune
BY ADAM ASHTON
Staff writer
June 6, 2015
He sought treatment for head injuries and PTSD at Madigan Army Medical Center in 2011 but was convinced doctors were not helping him. “He just kept telling me my anger was a mask for another emotion. What emotion! The only thing I felt was weak was talking about emotions.”


The soldier who committed the worst atrocities of the Afghanistan War acknowledged while asking for a reduced sentence last year that he had lost compassion for Iraqis and Afghans over the course of his four combat deployments with a Joint Base Lewis-McChord Stryker brigade.

“My mind was consumed by war,” the former Staff Sgt. Robert Bales wrote in a letter late last year to the senior Army officer at JBLM.

“I planted war and hate for the better part of 10 years and harvested violence,” he wrote. “After being in prison two years, I understand that what I thought was normal was the farthest thing from being normal.”

Bales, who was sentenced in August 2013 to life in prison for the killings of 16 Afghan civilians, including seven children, failed to persuade Lt. Gen. Stephen Lanza to overturn his conviction or modify his sentence. Lanza in March rejected Bales’ clemency bid after considering the weight of evidence in Bales’ court-martial, I Corps spokesman Col. Dave Johnson said Friday.
The News Tribune on Friday obtained 27 pages of letters Bales and his loved ones wrote to Lanza last fall while the general was considering whether to uphold Bales’ conviction. The set included letters from Bales’ wife, his in-laws and several soldiers who knew him on his earlier Iraq deployments when he was regarded as a sound infantryman.

His veteran friends described the qualities that led them to trust Bales in Iraq and expressed their remorse that they were not in Afghanistan with him at the time of his crimes.

“My only regret in life is that I wasn’t there in Afghanistan when Robert really needed a friend to see that he was struggling and pull him from the edge,” a JBLM staff sergeant wrote on Bales’ behalf.
read more here

Thursday, September 19, 2013

Mefloquine stopped for Green Berets and Special Forces almost 10 years too late

Mefloquine stopped for Green Berets and Special Forces almost 10 years too late
Wounded Times
Kathie Costos
September 19, 2013

In 2004, the VA issued a warning. "The drug is mefloquine, known by the brand name Lariam, which has been given to tens of thousands of soldiers since the war on terrorism began. Some of those soldiers say it has provoked severe mental and physical problems including suicidal and violent behavior, psychosis, convulsions and balance disorders."

In 2009 Spc. Adam Kuligowski's problems began because he couldn't sleep. The "21-year-old soldier was working six days a week, analyzing intelligence that the military gathered while he was serving in Afghanistan. He was gifted at his job and loved being a part of the 101st Airborne Division, just like his father and his great uncle. But Adam was tired and often late for work. His eyes were glassy and he was falling asleep while on duty. His room was messy and his uniform was dirty. His father, Mike Kuligowski, attributes his son's sleeplessness and depression to an anti-malarial medication called mefloquine that was found in his system. In rare cases, it can cause psychiatric symptoms such as anxiety, paranoia, depression, hallucination and psychotic behavior." That report came out in 2010.

By 2011 "dramatic about-face follows years of complaints and concerns that mefloquine caused psychiatric and physical side effects even as it was used around the globe as a front-line defense against the mosquito-borne disease that kills about 800,000 people a year. "Mefloquine is a zombie drug. It's dangerous, and it should have been killed off years ago," said Dr. Remington Nevin, an epidemiologist and Army major who has published research that he said showed the drug can be potentially toxic to the brain. He believes the drop in prescriptions is a tacit acknowledgment of the drug's serious problems."

In 2012 "Mefloquine, also called Lariam, has severe psychiatric side effects. Problems include psychotic behavior, paranoia and hallucinations. The drug has been implicated in numerous suicides and homicides, including deaths in the U.S. military. For years the military has used the weekly pill to help prevent malaria among deployed troops."

I can do this all day but the military just decided to stop giving it to Green Berets and other Special Forces. "Quoting the FDA’s July safety warning, the Surgeon General’s Office of the Army Special Operations Command sent a message to commanders and medical personnel last Friday ordering a halt in prescribing mefloquine for malaria prevention for the approximately 25,000 Green Berets, Rangers, Civil Affairs and Psychological Operations soldiers, command spokesman Lt. Col. Dave Connolly said."

They can pretend all they want that they didn't know what was going on before but the results have been deadly.
Green Berets, other elite Army forces ordered to stop taking anti-malarial drug mefloquine
By Associated Press
Thursday, September 19, 2013

WASHINGTON — The top doctor for Green Berets and other elite Army commandos has told troops to immediately stop taking mefloquine, an anti-malaria drug found to cause permanent brain damage in rare cases.

The ban among special operations forces is the latest development in a long-running controversy over mefloquine. The drug was developed by the Army in the 1970s and has been taken by millions of travelers and people in the military over the years. As alternatives were developed, it fell out of favor as the front-line defense against malaria, a mosquito-borne disease that international health officials say kills roughly 600,000 people a year.

The new prohibition among special operations forces follows a July 29 safety announcement by the Food and Drug Administration that it had strengthened warnings about neurologic side effects associated with the drug. The FDA added a boxed warning to the drug label, the most serious kind of warning, saying neurologic side effects like dizziness, loss of balance and ringing in the ears may become permanent.
read more here

Sunday, July 14, 2013

Anti-malarial drug linked to Afghan massacre a long time ago

What the hell is going on when reports do not research what they report on? Here is one more case of that.
MARCH 26, 2012 CNN reported Military Scrambles To Limit Malaria Drug Just After Afghanistan Massacre
That isn't the problem, even though reports on this drug go way back.

VA issued warning on Lariam in 2004

Spc. Adam Kuligowski's problems began because he couldn't sleep, April 2010

Army curbs prescriptions of anti-malaria drug Mefloquine NOVEMBER 20, 2011 and this one the same month. After four decades of use, the U.S. Army is banning the use of mefloquine (an anti-malaria drug) because of side effects.

Is Mefloquine the new Agent Orange? from August 2012

This report claims that it is "new information" but it isn't.
Anti-malarial drug linked to Afghan massacre
Soldier was taking mefloquine when he killed 16 civilians, report indicates
By Patricia Kime
Staff writer
Jul. 13, 2013

In less than a month, Army Staff Sgt. Robert Bales will be sentenced for the massacre of 16 Afghan civilians in March 2012.

His attorney, John Henry Browne, has not publicly disclosed whether he will use a mental health defense to fight for a parole-eligible sentence.

But an argument could be made that Bales, 40, was out of his mind:

■ He was treated for a traumatic brain injury resulting from a rollover accident in 2010 and possibly had post-traumatic stress disorder.

■ He admitted to using steroids, which can cause aggression and violence.

■ And new evidence suggests he was prescribed an anti-malaria drug known to cause hallucinations, aggression and psychotic behavior in some patients.
read more here

Thursday, May 30, 2013

Staff Sgt. Bales plea deal could cause retaliation in Afghanistan

This story leaves so many questions. Why did Bales go on the rampage? What medication was he on? There are stories circulating he had PTSD but PTSD does not usually cause anything close to this. There are reports about others committing crimes after being given Mefloquine and the Bales case caused the military so scramble to stop using it after this. There are also reports Bales had TBI and PTSD but so far there have been few answers as to why this happened. Now with troops still in Afghanistan, this plea deal could inflame retaliation against them. There needs to be answers and fast or this could get a lot worse.
Bales to plead guilty in Afghan massacre
Proposed deal would allow Joint Base Lewis-McChord soldier to avoid the death penalty.
Seattle Times staff and news services
May 29, 2013

In a proposed deal to avoid the death penalty, Staff Sgt. Robert Bales has agreed to plead guilty to killing 16 Afghans during a March 2012 tour of duty with an Army unit from Joint Base Lewis-McChord.

John Henry Browne said his client has “tremendous remorse” and would enter the plea at a court hearing at the base scheduled for June 5.

“The commanding general (at the base) has approved this so the only thing left is for the judge on the 5th to accept this plea,” Browne said Wednesday.

The Army judge has set aside a day for the plea agreement, and Bales is prepared to talk about the crimes.

Bales, 39, is accused of carrying out the most serious U.S. war crimes to emerge from more than a decade of American military involvement in Afghanistan.

In Afghanistan, the plea deal could inflame tensions. In interviews with The Associated Press in Kandahar in April, relatives of the victims became outraged at the notion Bales might escape the death penalty and even vowed revenge.

“For this one thing, we would kill 100 American soldiers,” said Mohammed Wazir, who had 11 relatives killed that night, including his mother and 2-year-old daughter.
read more here

Wednesday, February 13, 2013

A Potential Therapy for PTSD?

A Potential Therapy for PTSD?
TIME
By Remington Nevin
Feb. 13, 2013

The latest edition of the medical journal Psychiatric Annals features military researchers discussing how a procedure known as stellate ganglion block can effectively treat post-traumatic stress disorder (or PTSD).

Injecting a local anesthetic agent into the sympathetic nerve tissue at the base of the neck — a so-called stellate ganglion block (or SGB) – acts to numb signals which travel to centers deep in the brainstem and brain, commonly thought to be most responsible for PTSD.

The prospect of using a medical procedure to treat PTSD would be a paradigm shift for psychiatry.

That PTSD can be thought of an injury – something whose symptoms could be alleviated by injecting numbing medicine – would support the assertion that former Vice Army Chief of Staff General Peter Chiarelli has been advocating for some time that PTSD should be renamed PTSI – with an I for injury.

“It might seem counterintuitive that treating the peripheral nervous system could affect psychiatric conditions presumably mediated in the brain,” writes Dr. Cam Ritchie, my colleague and retired Army psychiatrist, in a press release for the journal heralding the news.

Unlike Dr. Ritchie, I am not so surprised by these findings.

My research focuses on the harmful effects of a class of drugs called quinolines, most notably the antimalarial drug mefloquine (or Lariam), which has been widely prescribed to deployed troops in Somalia, Iraq, and Afghanistan at high risk of PTSD. Many of the unpleasant symptoms caused by mefloquine, including anxiety, panic attacks, nightmares, and sleep problems, can often be difficult to distinguish from those attributed to PTSD.
read more here

Tuesday, August 7, 2012

Suicide Rate Now Likely Double or Triple Civil War

Disappointed in this study because they fail to address the fact that during the Civil War most died following amputations and serious wounds while today, they live on. Had more survived during those dark times in our history, there would have been more suicides. Plus the researchers would also have to take into account how news traveled back then.

How do they know? They don't. Read further down and see the word "estimate" along with what their research was.

What do they think "not deployed" means? Do they think the suicide had nothing to do with combat? How about the fact that most killed and maimed are killed by bombs? Do you think that might just be a factor in being so terrified they'd rather kill themselves now? What about Mefloquine? Hazing? Sexual Assaults? Or a lot of other causes for military suicides in the "31%" never deployed but must have passed their psychological tests, meaning they didn't have any issues when they signed up. When you have these kind of numbers coming out on military suicides, it shows how twisted some research can be when they answer the easy questions but never mention the obvious.

They used to shoot a lot of them for desertion too.
New Study: U.S. Military Suicide Rate Now Likely Double or Triple Civil War’s
By BARTLEY FRUEH AND JEFFREY SMITH
Time Battleland
August 6, 2012

Can medical data from the U.S. Civil War help us better understand military suicides?

Your recent Time cover story in the July 23 issue detailed the tragic facts that suicide rates among active-duty U.S. military personnel rose dramatically over the past decade. Military suicide rates doubled between 2001 and 2006, while remaining flat in the general population, with more military fatalities attributed to suicide than to actual combat in Afghanistan during that period.

To make matters worse, we do not understand why. Stressors related to military training, overseas deployment, transition back to civilian life, and combat are widely believed to be major driving factors. However, 31% of soldiers who committed suicide had never been deployed to a war zone. Furthermore, suicide rates in British military forces have also increased recently, though to a lesser degree, and do not exceed the rate of the general population.

Is there a lack of historical context?

Compounding our inability to understand this current phenomenon is the lack of adequate historical data to provide context on whether high suicide rates were typical of prior wars. Review of archival records from past wars might help shed some light on the current military suicide epidemic.

In a recent study (Frueh & Smith, 2012) we reviewed historical medical records on suicide deaths among Union forces during the U.S. Civil War (1861-1865), a brutal war that many consider the first modern one, and for the year immediately after the war to estimate the suicide rate among its Union combatants. We also reviewed these same historical records for data on rates of alcohol abuse and other probable psychiatric illnesses.
Read more

Monday, August 6, 2012

Is Mefloquine the new Agent Orange?

Is Mefloquine the new Agent Orange?
By Samantha A. Torrence
Aug 6, 2012

During Vietnam troops were exposed to Agent Orange. Later there was Gulf War Syndrome and depleted Uranium exposure. Now the military is dealing with a rash of military members with PTSD, and another chemical agent may be responsible for the diagnosis.

Malaria is a major concern to troops who are deployed around the world where contracting the disease is a risk. It is the Department of Defense policy that service members deployed to these areas must take an anti-malaria drug. There are various drugs available such as doxycycline, chloroquine, malarone, and mefloquine. Each drug comes with its unique problems such as high monetary cost in the case of malarone and photosensitivity, nausea, vomiting, and resistance in the cases of doxycycline and chloroquine. Most anti-malaria drugs must also be taken once a day which causes problems with consistency and potency for the soldiers who miss a dose and for that reason Mefloquine, which is only taken once a week, has been prescribed.

Mefloquine(Lariam®) may have a higher rate of compliance but it comes at a high cost to soldiers and American taxpayers. Mefloquine can cause brain injury, hallucinations, paranoia, psychosis and can predispose service members to Post Traumatic Stress Disorder (PTSD).

Read more

Tuesday, May 22, 2012

Troop Mental Ills: Psychiatric or Organic?

Troop Mental Ills: Psychiatric or Organic?
By ELSPETH CAMERON RITCHIE
May 22, 2012

There’s a continuing tension over whether mental disorders are “organic” or “psychological”. The first is easier to define — a brain injury caused by an insult, such as a bullet wound, blow to the head or bomb blast. “Psychological” is usually chalked up to bad parenting.

Two new debates raise this issue again. One is whether “post-traumatic stress disorder” should be called “post-traumatic brain injury”. The other is the emerging findings on “CTE” — chronic traumatic encephalopathy — which shows long-acting brain changes after concussions.

The term “shell shock” was later re-named “not yet diagnosed, nervous”, “battle fatigue”, “PTSD” and “combat stress reaction”. Now the term “post-traumatic stress injury” is being considered.


Dr. Remington Nevin has proposed that some of these reactions are actually the result of neurotoxic injuries from certain anti-malarial medications given to soldiers over the years, most recently mefloquine, or Lariam®.

read more here

Monday, March 26, 2012

Military Scrambles To Limit Malaria Drug Just After Afghanistan Massacre

It is looking more and more like the medication Bales was on was part of this.




When I wrote about the connection between what Bales is accused of doing and medications he was probably on for PTSD and TBI, I didn't think about Mefloquine. Army: PTSD treatable; some diagnosed return to war,,,with meds
By most accounts, Sgt. Robert Bales has PTSD and TBI. If true, then sending him back into combat, more than likely, included medications for both. Is anyone looking into what medications he was on and if they played a role in what happened more than PTSD and TBI? Most medications the troops are given come with clear warnings about side effects.

Looks like I should have.


Robert Bales Charged: Military Scrambles To Limit Malaria Drug Just After Afghanistan Massacre
Posted: 03/25/2012
Mark Benjamin

WASHINGTON -- Nine days after a U.S. soldier allegedly massacred 17 civilians in Afghanistan, a top-level Pentagon health official ordered a widespread, emergency review of the military’s use of a notorius anti-malaria drug called mefloquine.

Mefloquine, also called Lariam, has severe psychiatric side effects. Problems include psychotic behavior, paranoia and hallucinations. The drug has been implicated in numerous suicides and homicides, including deaths in the U.S. military. For years the military has used the weekly pill to help prevent malaria among deployed troops.

The U.S. Army nearly dropped use of mefloquine entirely in 2009 because of the dangers, now only using it in limited circumstances, including sometimes in Afghanistan. The 2009 order from the Army said soldiers who have suffered a traumatic brain injury should not be given the drug.

The soldier accused of grisly Afghanistan murders on March 17 of men, women and children, Staff Sgt. Robert Bales, suffered a traumatic brain injury in Iraq in 2010 during his third combat tour. According to New York Times reporting, repeated combat tours also increase the risk of post-traumatic stress disorder.

Bales' wife, Karilyn Bales, broke her silence in an interview Sunday with NBC's Matt Lauer, airing on Monday's Today show. "It is unbelievable to me. I have no idea what happened, but he would not -- he loves children. He would not do that," she said in excerpts released Sunday.

On March 20, Assistant Secretary of Defense for Health Affairs Jonathan Woodson ordered a new, urgent review to make sure that troops were not getting the drug inappropriately. The task order from Woodson, obtained by The Huffington Post, orders an immediate “review of mefloquine prescribing practices” to be completed by the following Monday, six days after the order was issued.
read more here

This was posted here January, 2008. Just goes to show what they new back then. It is a long post with some of the results of what they got wrong in human terms.

VA issued warning on Lariam in 2004
VA Warns Doctors About Lariam
United Press International
25 June 2004
WASHINGTON - The Department of Veterans Affairs is warning doctors to watch for long-term mental problems and other health effects from an anti-malaria drug given to soldiers in Afghanistan and Iraq.The drug is mefloquine, known by the brand name Lariam, which has been given to tens of thousands of soldiers since the war on terrorism began. Some of those soldiers say it has provoked severe mental and physical problems including suicidal and violent behavior, psychosis, convulsions and balance disorders.

Last year the Food and Drug Administration began warning that problems might last "long after" someone stops taking it.


Fort Campbell tries to stop soldier suicides

Spc. Adam Kuligowski's problems began because he couldn't sleep.
Last year, the 21-year-old soldier was working six days a week, analyzing intelligence that the military gathered while he was serving in Afghanistan. He was gifted at his job and loved being a part of the 101st Airborne Division, just like his father and his great uncle.

But Adam was tired and often late for work. His eyes were glassy and he was falling asleep while on duty. His room was messy and his uniform was dirty.

His father, Mike Kuligowski, attributes his son's sleeplessness and depression to an anti-malarial medication called mefloquine that was found in his system. In rare cases, it can cause psychiatric symptoms such as anxiety, paranoia, depression, hallucination and psychotic behavior.


Army curbs prescriptions of anti-malaria drug Mefloquine
Army curbs prescriptions of anti-malaria drug
LOS ANGELES (AP) – Almost four decades after inventing a potent anti-malarial drug, the U.S. Army has pushed it to the back of its medicine cabinet.

The dramatic about-face follows years of complaints and concerns that mefloquine caused psychiatric and physical side effects even as it was used around the globe as a front-line defense against the mosquito-borne disease that kills about 800,000 people a year.

"Mefloquine is a zombie drug. It's dangerous, and it should have been killed off years ago," said Dr. Remington Nevin, an epidemiologist and Army major who has published research that he said showed the drug can be potentially toxic to the brain. He believes the drop in prescriptions is a tacit acknowledgment of the drug's serious problems.

Tuesday, March 20, 2012

Ft. Bragg Soldier recovers from mysterious disease

Ft. Bragg Soldier recovers from mysterious disease
Susy Raybon
Military Community Examiner

It’s bad news/good news/bad news for the Army’s Chris Harriss who for the last two years was misdiagnosed more times than he can count and suffered longer than he cares to remember.

Harriss’ mystery illness has been the subject of many news articles as he, his wife, and a multitude of doctors grappled with his declining health.

Shaking hands, poor cognition, lack of strength and coordination were just a few of Harriss’ many symptoms.

Army doctors made one diagnosis of encephalopathy then switched to Parkinson’s disease and prescribed a host of medications to combat both, likely making him worse instead of better.

Eventually, Harriss was diagnosed with Lyme disease and powerful antibiotics were prescribed as the cure.

But Harriss’ Army doctors discontinued the medication after only a month, citing guidelines from the CDC that said “studies have shown that patients treated with prolonged courses of antibiotics do not do better than patients treated with placebo.”
read more here

Tuesday, November 22, 2011

When The Cure Is Worse Than The Disease

When The Cure Is Worse Than The Disease

November 22, 2011: After four decades of use, the U.S. Army is banning the use of mefloquine (an anti-malaria drug) because of side effects. Malaria is a debilitating (and sometimes fatal) disease found in most tropical areas. The medication to prevent it has always been unpleasant, either in terms of taste (no longer a problem) and side effects. These uncomfortable side effects are the big problem now. Sometimes it's a huge problem. Two years ago, PTSD (post-traumatic stress disorder) was found to interact in a fatal way with mefloquine. PTSD sufferers taking mefloquine resulted in more anxiety and suicidal behavior.

Once this interaction was discovered, troops with PTSD could no longer use the mefloquine. This impacted a lot of troops, and prevented them from being sent to some areas (like the Persian Gulf and Afghanistan) where malaria is a risk. The number of troops affected was considerable. In some parts of the world, less effective drugs, like doxycycline, could be substituted. But for doxycycline to work troops had to take the pill daily, without fail. The troops don’t always do that, partly because of the side effects (digestion problems and additional skin sensitivity) and the press of battlefield business.
read more here

Sunday, November 20, 2011

Army curbs prescriptions of anti-malaria drug Mefloquine

Army curbs prescriptions of anti-malaria drug
LOS ANGELES (AP) – Almost four decades after inventing a potent anti-malarial drug, the U.S. Army has pushed it to the back of its medicine cabinet.

The dramatic about-face follows years of complaints and concerns that mefloquine caused psychiatric and physical side effects even as it was used around the globe as a front-line defense against the mosquito-borne disease that kills about 800,000 people a year.

"Mefloquine is a zombie drug. It's dangerous, and it should have been killed off years ago," said Dr. Remington Nevin, an epidemiologist and Army major who has published research that he said showed the drug can be potentially toxic to the brain. He believes the drop in prescriptions is a tacit acknowledgment of the drug's serious problems.
read more here